Useful References

Burman C-F, Senn S 2003 Option values in drug development  Pharmaceut. Statist. 2(2) 113–125

 

Clarke C  2010 Quick win, fast fail  International Clinical Trials, Autumn 2010

 

Gittins JC  2003 Stochastic models for the planning of pharmaceutical research.  Journal of Statistical Theory and Applications, 2, 198-214

 

Kuhlmann J. 1999 Alternative strategies in drug development: clinical pharmacological aspects, Int. J. Clin. Pharmacol. Ther., 1999 Dec; 37(12): 575-83

 

Lendrem D. 1995  More haste, less development speed  Scrip Magazine, Dec 1995, pp 22-23

 

Lendrem DW, Lendrem BC  2012 Torching The Haystack: Modelling Fast-Fail Strategies in Drug Development, Drug Discovery Today In press.

 

Paul  SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL  2010   How to improve R&D productivity: the pharmaceutical industry's grand challenge Nature Reviews Drug Discovery 9, 203-214 

 

Peck, RW  2007  Driving earlier clinical attrition: if you want to find the needle, burn down the haystack. Considerations for biomarker development  Drug Discovery Today, 12, 289-294 

 

Senn  SJ  1996 Some statistical issues in project prioritization in the pharmaceutical industry  Statistics in Medicine, 15, 2689-2702

 

Schumpeter 2011 Fail Often, Fail Well  Economist April 14, 2011